The dGEMRIC Index was 14.4% lower in the medial index compartment (374 61 ms, mean SD) than in the lateral reference compartment (437 59 ms, mean SD) (P<0.001). The dGEMRIC Index of the medial diseased compartment correlated positively with both knee ﬂexor (r¼0.50, P¼0.001) and knee extensor

2018-04-01 · All patients were investigated in a standard 1.5 T MRI system (MAGNETOM Avanto, Siemens AG, Erlangen, Germany) with two flexible Body Matrix coils positioned directly over the hips. Patients received 0.2 mg/kg Gd(DTPA) 2− (Magnevist ® , Schering AG, Berlin, Germany) intravenously, followed by a 10 min timed walk. dGEMRIC imaging was performed 60 min after the injection.

MR imaging protocol Siemens Magnetom Trio 3.0 Tesla (T) magnets (Siemens AG, Erlangen, Germany) were used at three of the seven study sites, two sites used Signa Excite/Genesis 3.0 T MRI long-bore MR examinations were performed on a Siemens 1.5 T system (Magnetom Avanto, Siemens, Erlangen, Germany) and a body matrix phased array coil. The dGEMRIC scans were obtained after a double dose (0.4 mL/kg) intravenous injection of FDA approved contrast agent Magnevist (Gd-DTPA2; Berlex Laboratories, Wayne, NJ). Patients were The MRI imaging was performed using a 1.5 T Siemens Avanto MRI machine (Siemens Healthcare GmbH, Erlangen, Germany). The patients were examined using a standard knee MRI protocol [13] that was developed and used at Oslo University Hospital and included T2 mapping and a dGEMRIC [14]. The patients were scanned with all of the different sequences 2018-04-01 · All patients were investigated in a standard 1.5 T MRI system (MAGNETOM Avanto, Siemens AG, Erlangen, Germany) with two flexible Body Matrix coils positioned directly over the hips. Patients received 0.2 mg/kg Gd(DTPA) 2− (Magnevist ® , Schering AG, Berlin, Germany) intravenously, followed by a 10 min timed walk.

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dGEMRIC imaging was performed 60 min after the injection. The Siemens South Africa head office in Johannesburg has implemented a Distributed Energy System (DES) as a solution to tackle Africa’s energy transition. Th This definition approximates grade 2 knee OA based on the Kellgren and Lawrence scale 36 . MRISubjects were investigated with dGEMRIC 20.6 years (mean; range 18e23) after the injury, using a standard 1.5 T MRI system with a dedicated knee coil (Magnetom Vision; Siemens Medical Solutions, Erlangen, Germany). (dGEMRIC*) [3], sodium MR imaging [4, 5], and, very recently, chemical exchange-dependent saturation transfer (CEST) [6]. Of these techniques, only dGEMRIC has so far become clinically use-ful in cartilage repair imaging.

The MRI imaging was performed using a 1.5 T Siemens Avanto MRI machine (Siemens Healthcare GmbH, Erlangen, Germany). The patients were examined using a standard knee MRI protocol [13] that was developed and used at Oslo University Hospital and included T2 mapping and a dGEMRIC [14]. The patients were scanned with all of the different sequences

dGEMRIC and T2 mapping correlated moderately negative (Spearman coefficient r = -0.56, P = 0.0018) and T2 mapping and CEST moderately positive (r = 0.5, P = 0.007), while dGEMRIC and CEST did Elektrifiering, automation och digitalisering kräver innovativa lösningar: Upptäck Siemens som en stark partner, teknisk pionjär och ansvarig arbetsgivare. Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) allows an objective, noninvasive, and longitudinal quantification of biochemical cartilage properties.

Similar to the knee [ 4, 34 ], dGEMRIC is a promising tool to quantify cartilage healing or degeneration before and after joint-preserving hip surgery and to monitor the natural course of hip diseases.

Methods Cartilage The dGEMRIC method used in our study, and that was based on a dual–flip-angle technique, is sensitive to B 1 inhomogeneities, which are even worse at higher field strengths. Therefore, we performed dGEMRIC only at 3 T. Another limitation is the relatively long interval between dGEMRIC and sodium imaging examinations. In dGEMRIC, at the tibial plateau, the OA cartilage showed a higher change in the relaxation rate than intact cartilage. In addition, in delayed CT arthrography the contrast agent partition (Fig. 2C) at 60 minutes after the injection was higher in OA cartilage at lateral femoral condyle than in intact cartilage. Rationale and Objectives.

1-4 In these methods, anionic contrast agents are hypothesized to distribute into the cartilage in inverse proportion to the spatial distribution of fixed charge density in Thirty-five hips in 35 patients presenting with varying radiographic evidence of arthritis in the hip were imaged using a 3D isotropic fast T1 mapping dGEMRIC sequence (TR 15 msec, TE 3.27 msec, flip angles of 4.1 and 23.5 deg., Matrix size 192/192, 16 cm FoV, voxel size 0.8 x 0.8 x 0.8 mm) and a previously validated fast T1 mapping dGEMRIC sequence (voxel size 0.6 x 0.6 x 4 mm) for comparison. Specialistična bolnica je opremljena z najsodobnejšim aparatom znamke Siemens – MAGNETOM Avanto, A Tim System, z jakostjo magnetnega polja 1.5 T z visoko kvaliteto slike in z možnostjo snemanja z izjemno veliko hitrostjo. dGEMRIC – diagnosticiranja obrabe hrustanca. MR preiskava, ki omogoča specifično diagnosticiranje zgodnje obrabe Assessment of Cartilage Quality of Metacarpophalangeal Joints in Rheumatoid Arthritis Using Delayed Gd (DTPA)2-enhanced MRI of the Cartilage (dGEMRIC) at 3 T, LL-MKS-MO1A, 9003179, Falk Miese, The dGEMRIC method used in our study, and that was based on a dual–flip-angle technique, is sensitive to B 1 inhomogeneities, which are even worse at higher field strengths.
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Our aim was to determine the relationships between self-reported pain and disability, clinical variables, and serum leptin, and dGEMRIC indices in obese subjects with and without clinical knee osteoarthritis (OA). magnetic resonance imaging of cartilage (dGEMRIC index, ms). Images were taken using a Siemens Magnetom Symphony Quan-tum 1.5-T scanner (Siemens AG, Medical Solutions, Erlangen, Ger-many). Single sagittal slice images from the centre of the medial and lateral femoral condyles were taken from the knee with the highest K/L grade (affected knee). All MR imaging was performed on a 3T MR scanner (MAGNETOM Skyra, Siemens Healthcare, Erlangen, Germany) with a 15-channel Tx/Rx knee coil.

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The MRI imaging was performed using a 1.5 T Siemens Avanto MRI machine (Siemens Healthcare GmbH, Erlangen, Germany). The patients were examined using a standard knee MRI protocol [13] that was developed and used at Oslo University Hospital and included T2 mapping and a dGEMRIC [14]. The patients were scanned with all of the different sequences

Since we intended to perform the dGEMRIC analyses on the femoral and tibial articular cartilage from a single, 3 mm-thick slice through the median plane of the medial femoral condyle (Fig. 1 ROC-analysis demonstrated non-significant differences of T2 mapping vs CEST (P = 0.14), CEST vs dGEMRIC (P = 0.89), and T2 mapping vs dGEMRIC (P = 0.12). Conclusion: CEST is able to detect normal and damaged cartilage and is non-inferior in distinguishing both when compared to dGEMRIC and T2 mapping. Similar to the knee [ 4, 34 ], dGEMRIC is a promising tool to quantify cartilage healing or degeneration before and after joint-preserving hip surgery and to monitor the natural course of hip diseases. Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) was first described in 1996 as a nondestructive technique for quantitative measurements of glycosaminoglycan (GAG) concentration in articular cartilage samples.

Vladimir JELLUS, MR application developer | Cited by 5,176 | of Siemens | Read 48 publications | Contact Vladimir JELLUS

dGEMRIC was performed on a 1.5T Siemens Symphony magnet . Each subject recieved 0.2 mmol/kg of Gd(DTPA) 2 (Magnevist®, Bayer Healthcare) contrast agent, followed by a saline flush. Immediately after contrast administration , each subject walked for 10 minutes to promote diffusion of the contrast into synovial fluid and cartilage. dGEMRIC images were analyzed by an experienced musculoskeletal radiologist using the syngoMaplt software (Siemens). The dGEMRIC index was analyzed on seven di erent articular facets: the medial and lateral femoral condyle, femoral trochlea, medial and lateral tibial condyle and both patellar facets, before dGEMRIC, on demographic and KL grade data or on knee alignment data were excluded from the analysis (ﬁgure 1).

dGEMRIC requires intravenous injection of gadolinium contrast, however, which adds time, expense, and possible adverse reactions to the … Delayed Gadolinium Enhanced MRI of Cartilage (dGEMRIC) in Hip Dysplasia Marcel Dudda, M.D.; et al. Dept.